Both IVF and ICSI are popular fertility treatments. However, while IVF usually offers 60-70% success of fertilization, ICSI can fertilize 50-80% of the received eggs. This is because, in an ICSI procedure, a selected sperm is used to penetrate one egg. This raises the chances of fertilization. However, both the techniques have their pros and cons. Specialists at the best infertility hospital in Hyderabad say that the appropriate procedure is recommended based on age and specific infertility condition. Here is a detailed comparison of the ICSI and IVF treatment procedures.

IVF Procedure

In In Vitro Fertilisation (IVF), the doctor puts the eggs from a woman’s ovaries with the prepared sperm in a lab dish in culture media. The sperm and the eggs naturally fertilise overnight. For the next 3-5 days, an incubator allows the embryos to develop. An embryologist monitors them and picks the best embryos to be transferred to the woman’s womb.

ICSI Procedure

During Intra-Cystoplasmic Sperm Injection (ICSI), an embryologist chooses one sperm, procures it using a thin glass needle and injects it directly into an egg. After fertilization, the embryo is moved to the woman’s womb as done in IVF.

Main Difference Between ICSI and IVF

Unlike IVF, ICSI involves injecting every egg individually with a single selected sperm. So the sperm does not have to naturally penetrate one of the many eggs.

Candidates of ICSI

The ICSI procedure may be recommended to you in the following cases:

  • To overcome male fertility conditions like poor sperm mobility or a low sperm count
  • If the sperm contains major DNA damage
  • For a sperm directly obtained using electro-ejaculation or from the urine, testicles (using TESA) or epididymis (using PESA)
  • For frozen sperms
  • If the semen contains high antibody levels
  • If an earlier IVF procedure has failed

Candidates of IVF

IVF may be recommended to you in the following cases:

  • For cervical mucus or uterine conditions
  • For PCOS (polycystic ovarian syndrome)
  • For endometriosis
  • If conventional infertility treatments like injectable drugs, clomid or IUI (intrauterine insemination) fail
  • Unexplained infertility
  • Pelvic inflammatory disease
  • Absent, diseased or blocked fallopian tubes
  • Male factor infertility
  • Ovulatory dysfunction

Advantages of ICSI

ICSI usually provides the following advantages over an IVF cycle:

  • The embryos formed are of better quality.
  • It allows fertilization when the possibility of the same under regular insemination protocols is usually low.
  • It maximizes the possibility of receiving eggs for fertilization when the semen parameters are mostly not normal.
  • It has a higher possibility of successful fertilization.

Disadvantages of ICSI

ICSI has certain rare disadvantages as follows:

  • It may carry the possibility of unknown risks to your egg or the embryo.
  • The possibilities of birth defects in this method are a bit higher than in regular pregnancy.
  • If ICSI is combined with IVF, possibilities of pregnancy with multiples are higher.
  • It sometimes degenerates your egg instantly or damages the embryo.

Advantages of IVF

The main advantage offered by IVF is that it forms a viable embryo which carries higher chances of conception than with conventional treatments.

Disadvantages of IVF

IVF has the following disadvantages:

  • The success rate of fertilization in this procedure is not as high as the ICSI procedure.
  • The treated woman may get pregnant with multiples.
  • The treated woman may develop ovarian hyperstimulation syndrome due to fertility medications like HCG (human chorionic gonadotropin) injected to induce ovulation.
  • Birth defects like low birthweight and a premature delivery may occur.
  • A miscarriage may happen.
  • The treated woman may have an ectopic pregnancy.

If you are suffering from infertility conditions, get in touch with the best infertility hospital in Hyderabad to receive your suitable fertility treatment or learn its cost.